Darién can refer to places in Panama:

• Darién Province
• The town of Darién, founded by Vasco Núñez de Balboa.
• A short-lived colony of Scotland, see Darién scheme.
• Darién National Park

Darién can refer to places in the border region between Panama and Colombia:

• Darién Gap
• Gulf of Darién

Darién is a banana brand distributed in the United States by Turbana. Its sticker says "Darien #4011" along with the catchphrase "Delicious and nutritious bananas". It is a product of Columbia.

Darien was also the former transliteration of the name of Dalian, in China.

Darien is the name of several places in the United States of America:

• Darien, Connecticut
• Darien, Georgia
• Darien, Illinois - a suburb of Chicago
• Darien, New York
• Darien, Wisconsin
• Darien (town), Wisconsin

• Darien is the Anglicized name of Tuxedo Mask (Chiba Mamoru) in Sailor Moon

Darién