Clara Louise Maass (June 28, 1876—August 24, 1901) was an American nurse who died as a result of volunteering for medical experiments to study yellow fever.
In 1895 she became one of the first graduates of Newark German Hospital's Christina Trefz Training School for Nurses. By 1898, she had been promoted to head nurse at Newark German Hospital where she was known for her hard work and dedication to her profession.
During her army service she saw few battle injuries, instead caring mostly for soldiers suffering from infectious diseases like typhoid, malaria, dengue and yellow fever. She contracted dengue in Manila and was sent home.
The commission recruited human subjects because they did not know of any animals that could contract yellow fever. In the first recorded instance of informed consent in human experiments, volunteers were told that participation in the studies might cause their deaths. As an incentive, volunteers were paid US$100, which was a large amount at the time, with an additional $100 if the volunteer became ill.
In March 1901, Maass volunteered to be bitten by a Culex fasciata mosquito (now called Aedes aegypti) that had been allowed to feed on yellow fever patients. She contracted a mild case of the disease from which she quickly recovered. By this time, the researchers were certain that mosquitoes were the route of transmission, but lacked the scientific evidence to prove it because some volunteers who were bitten remained healthy.
Maass was buried in Colon Cemetery in Havana with military honors. Her body was moved to Fairmount Cemetery, Newark, New Jersey, on February 20, 1902.
1876 births | 1901 deaths | People from New Jersey | Lutherans | German-Americans | American nurses | Spanish-American War people | Female wartime nurses
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