The Cane River National Heritage Area is a United States National Heritage Area in the state of Louisiana. The heritage area is known for its spectacular Creole architecture as well as numerous other sites that preserve the multi-cultural history of the area. The heritage area includes the town of Natchitoches, Louisiana, the oldest community in the territory covered by the Louisiana Purchase. Cane River Creole National Historical Park also lies within the heritage area.

The roughly 116,000 acre (469.14 km²) Cane River National Heritage Area begins just south of Natchitoches and extends south and west for about 35 miles (56 kilometers along Cane River Lake and Interstate 49 to Monette's Ferry. Other sites in the heritage area include the Kate Chopin House and the state commemorative areas of Los Adaes, Fort Jesup, and Fort St. Jean Baptiste.

Protected areas of the United States