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Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. Expression of CYP1A2 appears to be induced by various dietary constituents (Fontana et al., 1999).
CYP1A2 Ligands
| Selected inducers, inhibitors and substrates of CYP1A21 | |
| Type | Agent |
| inducers | broccoli, brussel sprouts, chargrilled meat, insulin, modafinil, nafcillin, omeprazole, tobacco |
| inhibitors | amiodarone, cimetidine, fluoroquinolones (ciprofloxacin, etc), fluvoxamine, interferon, methoxsalen |
| substrates | amitriptyline, caffeine, clomipramine, clozapine, cyclobenzaprine, estradiol, fluvoxamine, haloperidol, imipramine, mexiletine, naproxen, olanzapine, ondansetron, paracetamol, propranolol, riluzole, ropivacaine, tacrine, theophylline, tizanidine, verapamil, warfarin, zileuton, zolmitriptan |
| Notes: | |
References
- Fontana RJ, Lown KS, Paine MF, et al. Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers. Gastroenterology. 1999 Jul;117(1):89-98. PMID 10381914
See also
"CYP1A2"