CPE may refer to:

• Canine Performance Events, a dog agility sanctioning organization
• Centrally planned economy
• Certificate of Proficiency in English, the fifth and highest level of the Cambridge University exams in English for Speakers of Other Languages
• Christian Paternalistic Ethic
• Clinical pastoral education is training for religious workers in pastoral care
• Common Professional Examination of England and Wales, a course which allows non-law graduates in England and Wales to convert to law after university
• Contrat première embauche (First Employment Contract), a French form of work contract allowing employers to more easily terminate workers' contracts, retracted by the government in Spring 2006
• Cupola Protective Ensemble, protective equipment worn by U.S. Army soldiers while manning a cupola
• Customer premises equipment, a term used in telecommunications
• Continuing Professional Education, a term used by CPAs and other professionals for the courses that they must take annually to keep their professional licenses current

As an IATA airport code, CPE refers to the Ing. Alberto Acuña Ongay International Airport in Campeche, Campeche, Mexico.

CpE (when written in CamelCase) can be an abbreviation for Computer engineering.

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