Conrad Hal Waddington FRS FRSE (1905 — 1975), known to his friends as "Wad", was a developmental biologist, paleontologist, geneticist, embryologist and philosopher. He also laid the foundations for systems biology, and had wide interests that included poetry and painting, as well as left-wing political leanings. He was the father of noted mathematician Dusa McDuff.

His personal papers are largely kept at Edinburgh University library.

The Epigenetic Landscape

Waddington's epigenetic landscape is a metaphor for how gene regulation determines development. One is asked to imagine a number of marbles rolling down a hill towards a wall. The marbles will compete for the grooves on the slope, and come to rest at the lowest points. These points represent the eventual cell fates, that is, tissue types.

Waddington also coined other essential concepts, such as canalisation, which refers to the ability of an organism to produce the same phenotype in various different environments.

Waddington tried to reconcile Jean-Baptiste Lamarck's ideas on the inheritance of acquired characters with modern biology, with moderate success.

Waddington as organiser

Waddington was very active in advancing biology as a discipline. He contributed to a book on the role of the sciences in times of war, and helped set up several professional bodies representing biology as a discipline. A remarkable number of his contemporary colleagues in Edinburgh became Fellows of the Royal Society during his time there, or shortly thereafter.

Selected works

• Waddington, C. H. (1946). How animals develop. London : George Allen & Unwin Ltd.
• Waddington, C. H. (1947). Organisers & genes. Cambridge: Cambridge University Press.
• Waddington, C. H. (1956). Principles of Embryology. London : George Allen & Unwin.
• Waddington, C. H (1959). Biological organisation cellular and subcellular : proceedings of a Symposium. London: Pergamon Press.
• Waddington, C. H (1960). The ethical animal. London : George Allen & Unwin.
• Waddington, C. H (1961). The human evolutionary system. En: Michael Banton (Ed.), Darwinism and the Study of Society. London: Tavistock.
• Waddington, C. H. (1966). Principles of development and differentiation. New York: Macmillan Company.
• Waddington, C. H. (1966). New patterns in genetics and development. New York: Columbia University Press.
• Waddington, C. H., ed. (1968-72). Towards a Theoretical Biology. 4 vols. Edinburgh: Edinburgh University Press.

See also

• Epigenetic inheritance

External links

• NAHSTE Project Record of C.H. Waddington
• Induction and the Origin of Developmental Genetics - works by Salome Gluecksohn-Schoenhimer and Conrad Hal Waddington
• Epigenetics News

1905 births | 1975 deaths | Biologists | Fellows of the Royal Society | Fellows of the Royal Society of Edinburgh

Conrad Hal Waddington