Brunner's glands are submucosal glands located throughout the duodenum. The main function of these glands is to produce an alkaline secretion (containing bicarbonate) in order to:

• protect the duodenum from the acidic content of chyme (which is introduced into the duodenum from the stomach);
• provide an alkaline condition for the intestinal enzymes to be active;
• lubricate the intestinal walls.

Digestive system