Brian Murphy may refer to:

• A British actor most noted for his role as George Roper in the sitcom George and Mildred
• A former mayor of Moncton in New Brunswick, Canada
• A former captain of the Zimbabwean cricket team
• A mathematician
• An ice hockey player in the National Hockey League
• A musical director for theatre productions in the Los Angeles area
• A pianist, composer and arranger (Brian M. Murphy)
• The California college administrator and current president of De Anza College in Cupertino, CA, USA