ALS may stand for:

• Amyotrophic lateral sclerosis, a form of motor neurone disease more commonly known as Lou Gehrig's disease or Maladie de Charcot
• Advanced Life Support, a protocolised form of cardiopulmonary resuscitation
• Automatic Landing System, an instrument based Landing System
• Audio Lossless Coding, part of the MPEG-4 standard for audio/video compression
• Advanced Light System, instrument used by investigators, an UV light
• Advanced Light Source, a synchrotron radiation source at Lawrence Berkeley National Laboratory in California
• Anterolateral system, a pathway in the central nervous system that carries pain and temperature information from the body to the brain
• Anti Lag System, an engine control program used on race cars to eliminate turbo lag

ALS | ALS