22nd century BC

2217 BC – 2193 BC — Nomadic invasions of Akkad.
2181 BC — Egypt: Pharaoh Nitocris died. End of Sixth Dynasty, start of Seventh Dynasty. Pharaoh Neferkara I started to reign.
2173 BC — Egypt: End of Seventh Dynasty, start of Eighth Dynasty.
2160 BC — Egypt: Pharaoh Neferirkara died. End of Eighth Dynasty, start of Ninth Dynasty. Pharaoh Neferkare started to reign.
ca. 2160 BC — beginning of Middle Minoan period in Crete
ca. 2144 BC — Gudea, the ruler (ensi) of the city of Lagash, started to reign.
2138 BC — Babylon: A solar eclipse on 9 May and a lunar eclipse on 24 May occurred and are believed to be the double eclipse that took place 23 years after the ascension of king Shulgi of Babylon by those holding to the long chronology.
2130 BC — Egypt: End of Ninth Dynasty, start of Tenth Dynasty. Ninth Dynasty wars in Egypt started.
2124 BC — Gudea, the ruler (ensi) of the city of Lagash, died.
2116 BC – 2110 BC — Uruk-Gutian war.
2112 BC – 2095 BC — Sumerian campaigns of Ur-Nammu.

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