Gourt Home::Gourt :: 17-Hydroxyprogesterone
| pregn-4-ene-3,20-dione,17hydroxy | |
| CAS number * | |
| Empirical formula | C21H30O3 |
| Molecular weight | 330.22 |
| Bioavailability | |
| Metabolism | Liver |
| Elimination half life | |
| Excretion | |
| Pregnancy category | (USA), |
| Physical properties | |
| Melting point | 219-220°C |
| Specific rotation *D | |
17-Hydroxyprogesterone (17-OH progesterone or 17OHP) is a C-21 steroid hormone produced in the synthesis of glucocorticoids and sex steroids. It is derived from progesterone via 17-hydroxylase, a P450c17 enzyme, or from 17-hydroxypregnenolone via 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase. As a hormone, 17OHP also interacts with the progesterone receptor.
This hormone is primarily produced in the adrenal glands and to some degree in the gonads, specifically the corpus luteum of the ovary. Normal levels are 3-90 ng/dl in children, and in women, 15-70 ng/dl prior to ovulation, and 35-290 ng/dl during the luteal phase.
Clinical use
Measurements of levels of 17-hydroxyprogesterone are useful in the evaluation of patients with suspected congenital adrenal hyperplasia as the typical enzymes that are defective, namely 21-hydroxylase and 11β-hydroxylase, lead to a build-up of 17OHP. In contrast, the rare patient with 17α-hydroxylase deficiency will have very low or undetectable levels of 17OHP. 17OHP levels can also be used to measure contribution of progestational activity of the corpus luteum during pregnancy as progesterone but not 17OHP is also contributed by the placenta.
The application of 17OHP has been shown to be useful to delay premature labor in pregnancy.Yemini M, Borenstein R, Dreazen, et al. Prevention of premature labor by 17 alpha-hydroxyprogesterone caproate. Am J Obstet Gynecol. 1985;151(5):574-7.PMID 3976757. Meis PJ; Society for Maternal-Fetal Medicine. 17 hydroxyprogesterone for the prevention of preterm delivery. Obstet Gynecol. 2005;105:1128-35.PMID 15863556.
References
External links
"17-Hydroxyprogesterone"