Events

• March - With the death of Ferdinand II of Aragon, his grandson Charles of Ghent becomes King of Spain as Carlos I.
• April 23 - The Reinheitsgebot is instituted in Ingolstadt, Bavaria regulating the purity of beer permissible for sale.
• July - Selim I of the Ottoman Empire declares war on the Mameluks and invades Syria.
• August 13 - Treaty of Noyon - Peace between France and Spain. Francis recognizes Charles's claim to Naples, and Charles recognizes Francis's claim to Milan.
• August 24 - Battle of Merj-Dabik. The Ottomans defeat the Mameluks, who abandon Syria.
• October 28 - Battle of Yaunis Khan. Turkish forces under the Grand Vizier Sinan Pasha defeat the Mameluks near Gaza.
• December 4 - Treaty of Brussels - Peace between France and the Empire.
• Pedro de Solis discovers the Río de la Plata.
• The Concordat of Bologna

Literature

• Ludovico Ariosto - Orlando Furioso.
• Desiderius Erasmus - new Latin translation of the New Testament.
• Thomas More - Utopia.

Births

• January 1 - Margareta Leijonhufvud, queen of Gustav I of Sweden (died 1551)
• February 18 - Queen Mary I of England (died 1558)
• March 26 - Conrad Gessner, Swiss naturalist (died 1565)
• Georg Fabricius, Protestant German poet (died 1571)
• John Foxe, biographer (died 1587)
• James Hamilton, 2nd Earl of Arran (died 1572)
• Martin Heilwig, Silesian cartography (died 1574)
• Matthew Stewart, 4th Earl of Lennox (died 1571)
• Charlotte de Valois, 6 (died 1524)
• Manco Inca Yupanqui, ruler of the Inca (died 1544)
• Cangali khan, khan of Qasim and Kazan

Deaths

• March 13 - King Ladislaus II of Bohemia and Hungary (b. 1456)
• March 17 - Giuliano di Lorenzo de' Medici, ruler of Florence (b. 1478)
• April 25 - John Yonge, English diplomat (born 1467)
• June 23 - King Ferdinand II of Aragon (born 1452)
• December 13 - Johannes Trithemius, German scholar and cryptographer (born 1462)
• Giovanni Bellini, Italian painter (born 1430)
• August - Hieronymus Bosch, Dutch painter (born 1450)
• Juan Díaz de Solís, Spanish navigator and explorer (born 1470)
• King John III of Navarre (born 1469)
• Giuliano da Sangallo, Italian sculptor and architect (born 1443)

1516

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